Description
COMPOSITION
Each Tablet Contains: Anastrozole 1 mg
PHARMACOLOGICAL CLASSIFICATION
ATC Code: L02B G 03(Enzyme Inhibitor)
PHARMACOLOGY
Anastrozole is a potent and highly selective non-steroidal aromatase inhibitor. In postmenopausal women, estradiol is produced primarily from the conversion of androstenedione to estrone through the aromatase enzyme complex in peripheral tissues. Estrone is subsequently converted to estradiol. Reducing circulating estradiol levels has been shown to produce a beneficial effect in women with breast cancer. In postmenopausal women, Anastrozole Tablets at a daily dose of 1 mg produced estradiol suppression of greater than 80% using a highly sensitive assay. Anastrozole does not possess any progestogenic, androgenic or oestrogenicactivity.
INDICATIONS
Treatment of advanced breast cancer in postmenopausal women. Efficacy has not been demonstrated in oestrogen receptor negative patients unless they had a previous positive clinical response to tamoxifen.
Adjuvant treatment of postmenopausal women with hormone receptor positive early invasive breast cancer.
Adjuvant treatment of early breast cancer in hormone receptor positive postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen.
CONTRAINDICATIONS
Anastrozole is contraindicated in: Premenopausal women.
Pregnant or lactating women.
Patients with severe renal impairment (creatinine clearance less than 20 ml/min).
Patients with moderate or severe hepatic disease.
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